Dogs, both pedigree and cross breeds, can be affected with genetic problems. Those known to sometimes occur in English Setters can include congenital deafness, which was reported as affecting 12.4 percent of the 701 English Setters tested by the Louisiana State University in 2010. As at 2013, there has not been any detailed research on this condition undertaken in the UK; autoimmune thyroiditis, which was shown to affect 26.2 percent of 747 English Setters examined between January 1974 until December 2012 in an Orthopedic Foundation for Animals listing; canine hypothyroidism; elbow dysplasia; and allergies, which can include some sensitivity to certain food ingredients and also skin conditions, are known to occur.
In 2004, the U.K. Kennel Club established the Accredited Breeders Scheme, which was later called the Assured Breeders Scheme (ABS). The scheme received UKAS accreditation in April 2013. ABS members are required to adhere to additional criteria than those necessary for basic KC registration. Among the extra requirements is "Ensuring that the parents of each litter are readily identifiable by either Microchip, Tattoo or DNA profile." As at March 2013, breeders of English Setters who are members of the ABS must screen for hip dysplasia. Some members of the breed may be affected by cancer and this was identified as the most common cause of death of English Setters in a survey undertaken by the Kennel Club; the age of death from this disease was mainly after reaching ten years of age. However, the survey had only received a small response rate. Life expectancy is between 11 and 12 years, though 13 to 15 years is not uncommon.